As of 2025-12-16, the Relative Valuation of Spero Therapeutics Inc (SPRO) is (16.55) USD. This relative valuation is based on P/E multiples. With the latest stock price at 2.29 USD, the upside of Spero Therapeutics Inc based on Relative Valuation is -822.9%.
The range of the Relative Valuation is (13.32) - (17.92) USD.
Note: valuation result may not be accurate due to the company's negative earnings.
| Range | Selected | |
| Trailing P/E multiples | 13.8x - 18.8x | 17.3x |
| Forward P/E multiples | 14.0x - 21.1x | 17.5x |
| Fair Price | (13.32) - (17.92) | (16.55) |
| Upside | -681.6% - -882.7% | -822.9% |
| Date | P/E |
| 2025-12-15 | -2.41 |
| 2025-12-12 | -2.44 |
| 2025-12-11 | -2.47 |
| 2025-12-10 | -2.45 |
| 2025-12-09 | -2.45 |
| 2025-12-08 | -2.43 |
| 2025-12-05 | -2.38 |
| 2025-12-04 | -2.40 |
| 2025-12-03 | -2.40 |
| 2025-12-02 | -2.31 |
| 2025-12-01 | -2.39 |
| 2025-11-28 | -2.52 |
| 2025-11-26 | -2.45 |
| 2025-11-25 | -2.46 |
| 2025-11-24 | -2.50 |
| 2025-11-21 | -2.43 |
| 2025-11-20 | -2.38 |
| 2025-11-19 | -2.50 |
| 2025-11-18 | -2.60 |
| 2025-11-17 | -2.55 |
| 2025-11-14 | -2.53 |
| 2025-11-13 | -2.56 |
| 2025-11-12 | -2.80 |
| 2025-11-11 | -2.75 |
| 2025-11-10 | -2.63 |
| 2025-11-07 | -2.59 |
| 2025-11-06 | -2.51 |
| 2025-11-05 | -2.55 |
| 2025-11-04 | -2.47 |
| 2025-11-03 | -2.50 |
| 2025-10-31 | -2.55 |
| 2025-10-30 | -2.48 |
| 2025-10-29 | -2.45 |
| 2025-10-28 | -2.50 |
| 2025-10-27 | -2.41 |
| 2025-10-24 | -2.32 |
| 2025-10-23 | -2.31 |
| 2025-10-22 | -2.36 |
| 2025-10-21 | -2.49 |
| 2025-10-20 | -2.41 |
| 2025-10-17 | -2.32 |
| 2025-10-16 | -2.47 |
| 2025-10-15 | -2.62 |
| 2025-10-14 | -2.48 |
| 2025-10-13 | -2.41 |
| 2025-10-10 | -2.36 |
| 2025-10-09 | -2.48 |
| 2025-10-08 | -2.40 |
| 2025-10-07 | -2.27 |
| 2025-10-06 | -2.20 |