As of 2025-09-15, the Relative Valuation of Spero Therapeutics Inc (SPRO) is (12.62) USD. This relative valuation is based on P/E multiples. With the latest stock price at 1.90 USD, the upside of Spero Therapeutics Inc based on Relative Valuation is -764.2%.
The range of the Relative Valuation is (10.13) - (14.42) USD.
Note: valuation result may not be accurate due to the company's negative earnings.
| Range | Selected | |
| Trailing P/E multiples | 10.6x - 15.1x | 13.3x |
| Forward P/E multiples | 10.2x - 16.6x | 13.2x |
| Fair Price | (10.13) - (14.42) | (12.62) |
| Upside | -633.3% - -858.9% | -764.2% |
| Date | P/E |
| 2025-09-10 | -2.04 |
| 2025-09-09 | -2.08 |
| 2025-09-08 | -2.09 |
| 2025-09-05 | -2.26 |
| 2025-09-04 | -2.25 |
| 2025-09-03 | -2.18 |
| 2025-09-02 | -2.15 |
| 2025-08-29 | -2.17 |
| 2025-08-28 | -2.10 |
| 2025-08-27 | -2.08 |
| 2025-08-26 | -1.94 |
| 2025-08-25 | -1.94 |
| 2025-08-22 | -1.96 |
| 2025-08-21 | -1.95 |
| 2025-08-20 | -1.92 |
| 2025-08-19 | -1.93 |
| 2025-08-18 | -2.01 |
| 2025-08-15 | -2.01 |
| 2025-08-14 | -2.08 |
| 2025-08-13 | -2.03 |
| 2025-08-12 | -2.48 |
| 2025-08-11 | -2.31 |
| 2025-08-08 | -2.30 |
| 2025-08-07 | -2.28 |
| 2025-08-06 | -2.37 |
| 2025-08-05 | -2.23 |
| 2025-08-04 | -2.37 |
| 2025-08-01 | -2.41 |
| 2025-07-31 | -2.44 |
| 2025-07-30 | -2.28 |
| 2025-07-29 | -2.31 |
| 2025-07-28 | -2.41 |
| 2025-07-25 | -2.45 |
| 2025-07-24 | -2.47 |
| 2025-07-23 | -2.50 |
| 2025-07-22 | -2.53 |
| 2025-07-21 | -2.44 |
| 2025-07-18 | -2.49 |
| 2025-07-17 | -2.60 |
| 2025-07-16 | -2.59 |
| 2025-07-15 | -2.61 |
| 2025-07-14 | -2.77 |
| 2025-07-11 | -2.95 |
| 2025-07-10 | -2.98 |
| 2025-07-09 | -3.19 |
| 2025-07-08 | -3.09 |
| 2025-07-07 | -3.04 |
| 2025-07-03 | -3.06 |
| 2025-07-02 | -3.04 |
| 2025-07-01 | -3.04 |