As of 2025-10-17, the Relative Valuation of Spero Therapeutics Inc (SPRO) is (12.81) USD. This relative valuation is based on P/E multiples. With the latest stock price at 2.35 USD, the upside of Spero Therapeutics Inc based on Relative Valuation is -645.1%.
The range of the Relative Valuation is (10.29) - (14.88) USD.
Note: valuation result may not be accurate due to the company's negative earnings.
| Range | Selected | |
| Trailing P/E multiples | 10.8x - 15.6x | 13.5x |
| Forward P/E multiples | 10.7x - 17.1x | 13.4x |
| Fair Price | (10.29) - (14.88) | (12.81) |
| Upside | -537.7% - -733.0% | -645.1% |
| Date | P/E |
| 2025-10-16 | -2.47 |
| 2025-10-15 | -2.61 |
| 2025-10-14 | -2.48 |
| 2025-10-13 | -2.40 |
| 2025-10-10 | -2.36 |
| 2025-10-09 | -2.48 |
| 2025-10-08 | -2.39 |
| 2025-10-07 | -2.27 |
| 2025-10-06 | -2.19 |
| 2025-10-03 | -2.15 |
| 2025-10-02 | -2.13 |
| 2025-10-01 | -2.06 |
| 2025-09-30 | -1.97 |
| 2025-09-29 | -1.99 |
| 2025-09-26 | -1.98 |
| 2025-09-25 | -2.04 |
| 2025-09-24 | -2.07 |
| 2025-09-23 | -2.11 |
| 2025-09-22 | -2.13 |
| 2025-09-19 | -2.10 |
| 2025-09-18 | -2.10 |
| 2025-09-17 | -1.99 |
| 2025-09-16 | -1.99 |
| 2025-09-15 | -1.97 |
| 2025-09-12 | -1.99 |
| 2025-09-11 | -2.05 |
| 2025-09-10 | -2.04 |
| 2025-09-09 | -2.08 |
| 2025-09-08 | -2.09 |
| 2025-09-05 | -2.26 |
| 2025-09-04 | -2.25 |
| 2025-09-03 | -2.18 |
| 2025-09-02 | -2.15 |
| 2025-08-29 | -2.17 |
| 2025-08-28 | -2.10 |
| 2025-08-27 | -2.08 |
| 2025-08-26 | -1.94 |
| 2025-08-25 | -1.94 |
| 2025-08-22 | -1.96 |
| 2025-08-21 | -1.95 |
| 2025-08-20 | -1.92 |
| 2025-08-19 | -1.93 |
| 2025-08-18 | -2.01 |
| 2025-08-15 | -2.01 |
| 2025-08-14 | -2.08 |
| 2025-08-13 | -2.03 |
| 2025-08-12 | -2.48 |
| 2025-08-11 | -2.31 |
| 2025-08-08 | -2.30 |
| 2025-08-07 | -2.28 |