As of 2026-03-17, the Relative Valuation of Spero Therapeutics Inc (SPRO) is (17.76) USD. This relative valuation is based on P/E multiples. With the latest stock price at 2.58 USD, the upside of Spero Therapeutics Inc based on Relative Valuation is -788.3%.
The range of the Relative Valuation is (16.81) - (17.90) USD.
Note: valuation result may not be accurate due to the company's negative earnings.
| Range | Selected | |
| Trailing P/E multiples | 21.1x - 25.6x | 23.4x |
| Forward P/E multiples | 21.6x - 23.0x | 22.3x |
| Fair Price | (16.81) - (17.90) | (17.76) |
| Upside | -751.4% - -793.6% | -788.3% |
| Date | P/E |
| 2026-03-13 | -3.32 |
| 2026-03-12 | -3.33 |
| 2026-03-11 | -3.33 |
| 2026-03-10 | -3.15 |
| 2026-03-09 | -2.98 |
| 2026-03-06 | -2.96 |
| 2026-03-05 | -2.94 |
| 2026-03-04 | -2.94 |
| 2026-03-03 | -2.81 |
| 2026-03-02 | -2.81 |
| 2026-02-27 | -2.79 |
| 2026-02-26 | -2.84 |
| 2026-02-25 | -2.85 |
| 2026-02-24 | -2.87 |
| 2026-02-23 | -2.88 |
| 2026-02-20 | -2.96 |
| 2026-02-19 | -3.08 |
| 2026-02-18 | -2.99 |
| 2026-02-17 | -3.02 |
| 2026-02-13 | -3.07 |
| 2026-02-12 | -3.06 |
| 2026-02-11 | -3.05 |
| 2026-02-10 | -3.03 |
| 2026-02-09 | -3.03 |
| 2026-02-06 | -3.11 |
| 2026-02-05 | -2.96 |
| 2026-02-04 | -2.94 |
| 2026-02-03 | -2.75 |
| 2026-02-02 | -2.87 |
| 2026-01-30 | -2.81 |
| 2026-01-29 | -2.89 |
| 2026-01-28 | -2.87 |
| 2026-01-27 | -3.05 |
| 2026-01-26 | -3.15 |
| 2026-01-23 | -3.14 |
| 2026-01-22 | -3.15 |
| 2026-01-21 | -3.03 |
| 2026-01-20 | -3.06 |
| 2026-01-16 | -3.10 |
| 2026-01-15 | -3.08 |
| 2026-01-14 | -3.23 |
| 2026-01-13 | -3.15 |
| 2026-01-12 | -3.23 |
| 2026-01-09 | -3.28 |
| 2026-01-08 | -3.30 |
| 2026-01-07 | -3.34 |
| 2026-01-06 | -3.23 |
| 2026-01-05 | -3.12 |
| 2026-01-02 | -3.02 |
| 2025-12-31 | -2.99 |